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Sam is a nerdy, shy but intelligent secondary student at NAN school in VT

His parents are working abroad and he lives with his Uncle Jack and Aunt Tina.

He has a crush on his next door neighbor, Anna , who happens to be one of the few classmates who is nice to him.

Sam's only friend is Henry, who, though rich and good-looking, is similarly, although perhaps a self imposed outcast, due to his wealth and good looks. 

Sam's science class takes a field trip excursion to a science laboratory at a University.

The lab works on insects and has even managed to create a new species of "super-ant" through DNA manipulations and combinations.

While Sam is taking a photo of Anna for the school newspaper

One of these new genetically-altered ants escapes without anyone noticing and lands on his hand and bites him.

Sam comes home feeling ill and immediately goes to bed. At the genetic level, the venom injected by the spider bite begins to work strange magic on Sam.