First permanent European settlement in North America - St Augustine, present-day Florida - founded by the Spanish. North America is already inhabited by several distinct groups of people, who go into decline following the arrival of settlers.
Jamestown, Virginia, founded by English settlers, who begin growing tobacco.
Plymouth Colony, near Cape Cod, is founded by the Pilgrim Fathers, whose example is followed by other English Puritans in New England.
Hundreds of thousands of Africans brought over and sold into slavery to work on cotton and tobacco plantations.